Selank
Selank (TP-7)
Anxiety relief without sedation
Cognitive ★ 72
Half-life
Short, but biological effects last 24+ hours
Cycle
4-6 weeks on, 1-2 weeks off.
Storage
Lyophilized: freezer. Reconstituted: 2-8°C, 14-21 days.
Research
Approved in Russia as a medication, not in the USA/EU
About
A Russian nootropic peptide that reduces anxiety without sedation. Analog of tuftsin.
Mechanism
Modulates GABA and serotonin systems. Increases BDNF.
Dosage
250-500 mcg
1-2x per day (nasal)
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Draw to 10 units on a U-100 insulin syringe
5 mg · 1 mL BAC
Route
Intranasal
Duration
4-6 weeks
When to take: Morning or early afternoon. Avoid after 3 PM (may disrupt sleep).
Reconstitution
Vial size (mg): 5 mg · BAC water (mL): 1 mL · Concentration: 5000 mcg/mL
Most often used as a nasal spray. Each puff = 250-500 mcg.
Dosing reference
Units to draw at the typical dose range, per vial size.
| Vial | Water | Typical draw |
|---|---|---|
| 5 mg | 1 mL | 5–10 units |
| 10 mg | 1 mL | 2.5–5 units |
Benefits
- Anxiety relief without sedation
- Improved focus
- No addiction potential (unlike benzodiazepines)
- Stress resilience
- Improved mood
- Anti-inflammatory effects
Side effects
- Very well tolerated
- Rare: headache
- Nasal irritation (with intranasal use)
Gender notes
Same dose. Popular among 'high performers' with anxiety.
Cautions
- Pregnancy
- History of psychosis (caution)
- Other GABA-active medications (interaction)
Research
- Medvedev VE et al: Selank in generalized anxiety
Zhurnal Nevrologii i Psikhiatrii · 2014
Russian clinical trial showing significant reduction in anxiety vs placebo.
- Inozemtseva LS et al: Selank molecular mechanisms
Doklady Biological Sciences · 2008
Review of Selank's BDNF/GABA mechanisms.